Research

The oral environment

The oral environment is dynamic—
shaped continuously by eating, drinking, and daily habits.

As the tablet dissolves, it interacts with saliva,
allowing gradual dispersion across the mouth over time.

This extended presence supports the oral environment
between brushing.

Controlled release

Each tablet is engineered to dissolve slowly—
extending contact within the oral environment.

Size and density are calibrated
to influence how it sits,
how it activates,
and how it disperses over time.

This is not immediate release.
It's sustained interaction.

Designed for gradual interaction with saliva.

Formulation and function

The formulation combines xylitol and fluoride within a slow-dissolving format, designed for gradual interaction in the oral environment.

Xylitol has been widely studied in relation to oral environments and bacterial activity. Research has explored its interaction with acid-producing bacteria.

Fluoride contributes to the maintenance of tooth mineralisation. It's gold-standard role in enamel has been documented within clinical literature. Not more fluoride, instead fluoride used intelligently.

Delivered in controlled amounts, the formulation is designed for use across the day.

Research context

Selected studies informing our formulation approach.

Xylitol and oral balance

Xylitol has been extensively studied in relation to oral environments, particularly its interaction with plaque bacteria and salivary flow. A consistent body of research suggests it can contribute to conditions that are less favourable to acid-producing bacteria when used appropriately.

Informed by a body of peer-reviewed scientific literature.

Including publications in:

Journal of Dental Research · Caries Research · Community Dentistry and Oral Epidemiology

ALHumaid J, Bamashmous M. Meta-analysis on the Effectiveness of Xylitol in Caries Prevention. J Int Soc Prev Community Dent. 2022 Apr 8;12(2):133-138.

Söderling E, Pienihäkkinen K. Effects of xylitol and erythritol consumption on mutans streptococci and the oral microbiota: a systematic review. Acta Odontol Scand. 2020 Nov;78(8):599-608.

Liang NL, Luo BW, Sun IG, Chu CH, Duangthip D. Clinical Effects of Sugar Substitutes on Cariogenic Bacteria: A Systematic Review and Meta-Analysis. Int Dent J. 2024 Oct;74(5):987-998.

Janakiram C, Deepan Kumar CV, Joseph J. Xylitol in preventing dental caries: A systematic review and meta-analyses. J Nat Sci Biol Med. 2017 Jan-Jun;8(1):16-21.

Fluoride and enamel mineralisation

Fluoride is one of the most widely researched ingredients in oral care, with a well-established role in supporting tooth mineralisation. Research consistently highlights the importance of regular, low-level exposure as part of daily oral routines.

Informed by a body of peer-reviewed scientific literature.

Including publications in:

Journal of Clinical Dentistry · J Am Dent Association · Cochrane Database Syst Rev.

Griffin SO, Regnier E, Griffin PM, Huntley V. Effectiveness of fluoride in preventing caries in adults. J Dent Res. 2007 May;86(5):410-5.

Tubert-Jeannin S, Auclair C, Amsallem E, Tramini P, Gerbaud L, Ruffieux C, Schulte AG, Koch MJ, Rège-Walther M, Ismail A. Cochrane Database Syst Rev. 2011 Dec 7;2011(12)

Ismail AI, Hasson H. Fluoride supplements, dental caries and fluorosis: a systematic review. J Am Dent Assoc. 2008 Nov;139(11):1457-68.